We surmise that results obtained from the experiments described in this section cannot serve to understand the role of INaL in arrhythmogenesis.
1. Van Driessche W, Lindemann B: Quantity dependency out of currents through unmarried sodium-selective pores from inside the frog surface. Nature. 1979; 282 (5738): 519-520 PubMed Conceptual | Journalist Full Text message
It indicates brand new solid findings put forward from this manuscript are not warranted and i cannot agree the latest manuscript in this function
This new writers has actually explained many of the questions We raised when you look at the my personal earlier in the day review. Sadly, all major issues have not been addressed from this up-date. When i made in academic writing companies my early in the day remark, I deem they impractical that most those points will be repaired simply by the a few added sentences. Alternatively there are still specific basic concerns towards fresh construction and you may, extremely vitally, on studies.
It means new solid conclusions submit by this manuscript is actually perhaps not rationalized and i cannot approve this new manuscript inside form
The article writers has actually explained several of the inquiries I elevated during the my personal earlier in the day remark. Regrettably, every biggest problems haven’t been managed from this inform. As i manufactured in my personal earlier opinion, We deem they unlikely that most people situations would be fixed merely by a number of additional sentences. As an alternative there are particular important inquiries towards the fresh design and you may, most critically, on the study.
- The best issue is when I then followed the description out-of the methods in the earlier adaptation it actually was you can to decode, which have nearly primary accuracy, any random stimulus labels I chose. Get a hold of getting examples of which reanalysis. No matter whether we imagine that actual stimuli appeared during the an after big date otherwise are continuously alternating anywhere between rule and quiet, brand new decryption is definitely alongside prime. This will be indicative your decryption has nothing to do to your actual stimuli read by the Transmitter it is opportunistically exploiting various other possess regarding the studies. This new handle study the latest people performed, treating the stimulus brands, cannot target this dilemma since it is affected with equivalent problem. Basically, precisely what the classifier try presumably having fun with is the time who’s got enacted as recording already been.
- The cause of that is allegedly the people used low-independent research to possess knowledge and analysis. Of course I understand correctly (come across part step 3), random testing half of data products regarding an EEG trace are not separate data. Repeating the research 5 times – the fresh new control analysis the latest article writers performed – is not an adequate solution to target it concern. Randomly in search of samples out of a period of time series that features sluggish changes (including the slow trend interest one to allegedly dominates this type of tracks less than these situations) commonly invariably include solid temporary correlations. Find TemporalCorrelations.jpg set for 2D density histograms and you will a relationship matrix demonstrating so it.
- As the changed methods part provides more detail today, they remains confused about what studies were utilized. Conventional group investigation statement exactly what studies have (usual columns throughout the data matrix) and you may just what observations (typical rows) were used. Some thing would be an element however, typically this will be the latest various other EEG avenues or fMRI voxels etcetera. Findings are often go out situations. Here I assume the fresh new writers turned the fresh brutal samples towards the a great more place playing with principal parts research. It is not said in case your dimensionality is actually shorter utilising the eigenvalues. In any event, I guess the information examples (compiled from the 128 Hz) had been next made use of while the findings and also the EEG avenues transformed from the PCA were used as has. The fresh stimulus names was indeed assigned just like the To your otherwise Out-of for every decide to try. A couple of fifty% out of products (and you can brands) was then chose randomly having degree, together with other individuals was utilized having evaluation. Is this right?
